STRUCTURAL PROTEOMICS METHODS TO INTERROGATE THE CONFORMATIONS AND DYNAMICS OF INTRINSICALLY DISORDERED PROTEINS

Structural Proteomics Methods to Interrogate the Conformations and Dynamics of Intrinsically Disordered Proteins

Intrinsically disordered proteins (IDPs) and regions of intrinsic disorder (IDRs) are abundant in proteomes and are essential for many biological processes.Thus, they are often implicated in disease mechanisms, including neurodegeneration and cancer.The flexible nature of IDPs and IDRs provides many advantages, including (but not limited to) overco

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Targeting the prefrontal-supplementary motor network in obsessive-compulsive disorder with intensified electrical stimulation in two dosages: a randomized, controlled trial

Abstract Obsessive-compulsive disorder Denture Adhesives (OCD) is associated with a high disease burden, and treatment options are limited.We used intensified electrical stimulation in two dosages to target a main circuitry associated with the pathophysiology of OCD, left dorsolateral prefrontal cortex (l-DLPFC), and pre-supplementary motor area (p

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